Efficacy of oral versus subcutaneous methotrexate in children with juvenile idiopathic arthritis
نویسندگان
چکیده
Methods According to MTX-administration route, children were divided into four groups: sc, po, switching from po to sc and from sc to po. Based on joint counts (pain, swelling and limited range of motion), patient's and physician's visual analogue scale for disease activity (VAS) and erythrocyte sedimentation rate (ESR) or C-reactive protein (CRP), a combined overall disease activity score (entitled Co-score, CoS) was generated for each patient. Statistically paired T-test and ANCOVA were applied.
منابع مشابه
Paediatric rheumatology Methotrexate bioavailability after oral and subcutaneous administration in children with juvenile idiopathic arthritis
Objective To compare the bioavailability of oral and subcutaneous methotrexate (MTX) in children with juvenile idiopathic
متن کاملThe Efficacy of Subcutaneous Versus Oral Methotrexate in Patients with Juvenile Idiopathic Arthritis
The aim of modern treatment of JIA is rapid induction of disease control to prevent joint damage, to maximize physical function and to achieve a normal lifestyle2. Medications that slow the progression of Rheumatoid arthritis are called disease modifying anti Rheumatic drugs (DMARDs). American College of Rheumatology (ACR) recommends early use of DMARDs, so that they can slow or help inhibition...
متن کاملEfficacy of Subcutaneous Methotrexate in JIA Patients Who have Failed to Improve with Oral Methotrexate
Methotrexate is the most commonly used disease modifying anti-rheumatic drug (DMARDs) for rheumatoid arthritis1. However, some patients are intolerant to oral MTX despite folate supplementation and some patients do not respond adequately2. The route of administration of MTX in children with juvenile idiopathic arthritis (JIA) is not standardized and varies according to patient’s and treating ph...
متن کاملMethotrexate efficacy and tolerability after switching from oral to subcutaneous route of administration in juvenile idiopathic arthritis
OBJECTIVES Methotrexate (MTX) is one of the most frequently used, highly effective disease-modifying drugs in juvenile idiopathic arthritis (JIA) therapy. The drug can be administered orally or subcutaneously, but the efficacy and tolerance of these two routes of administration raise doubts in JIA patients. The aim of the study was to evaluate MTX efficacy and tolerability after switching from ...
متن کاملIntolerance in oral versus subcutaneous administration of methotrexate in patients with juvenile idiopathic arthritis: a cross-sectional, observational study
Introduction Methotrexate (MTX) is the cornerstone disease-modifying anti-rheumatic drug in juvenile idiopathic arthritis (JIA), because of its efficacy. Moreover, serious adverse events are rare. However, in Dutch patients, MTX intolerance, defined as gastro-intestinal side effects occurring not only after, but also before administration of MTX and when thinking of the drug, occurred frequentl...
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عنوان ژورنال:
دوره 6 شماره
صفحات -
تاریخ انتشار 2008